I would say that Pathfinder took 3.5e and made it less interesting to me, even though the game really is about 90% the same.
I'm kinda surprised to see 4e on here. Out of the box, the numbers just don't add up for the game, and then there's skill challenges. It does kinda make me ask, though: what's the difference between a board game and a PnP game? This question may be somewhat unique to me, however, since I have also, a long time ago, played Hero Quest
EDIT: Holy crap, I must have been like... 8 when I played that...