Templates
Dracolich
Shadow Dragon Template
Half Dragon
Gains: Senses, Resistance, Language, Breath Weapon
Type does not change
I find it funny that the fluff indicates they can't have offspring other than via magic, yet we have the Sorcerer class with draconic lineage. Don't recall if previous editions had this fluff.
There's no immediate downside to not being a Half-Dragon
Lycanthrope
Gains: Floor of a physical stat is set to X based on animal, and +1 AC in hybrid or animal form.
Only downside is perhaps the full moon, though the Wereboar entry leaves one to believe the curse can be controlled.
Vampire
Gains: Floor of physical scores set to 18, damage resistances, darkvision, traits, actions. Undead and alignment LE.
Assuming one gets past being a spawn, and is already of evil tenadancy, its interesting in that theres no crippling LA.