So Lord Orochi had long been super hyped as the leader of the Monster Association that had started as a normal human then ascended to ultimate lifeform, not only ruling the other top monsters thanks to its ultimate power but even curbstomping Garou.
Of course Saitama interrupts Lord Orochi's egomaniacal monologue and beats him whitout breaking a sweat.
Although technically took more than one punch that with needing to clear a path through all those draconic tentacles.