Seconding CHR dumping. It's a very viable strategy, and you don't actually lose much of the game by not having high CHR. You can still have a crapton of settlements, and you can still build them up as big as you want, it's just going to be a little bit more difficult on account of not sharing crafting materials between settlements, but you don't actually lose out much at all. Perfectly viable to have a Minuteman victory with CHR=1 if you so desire.
Another very dumpable stat is, surprisingly, Perception. If you don't like to use VATS a lot, there's a companion you can get pretty early in the game that can lockpick up to Expert level locks, meaning even Lockpicking isn't that much of a necessity. There's also a companion that can unlock up to Expert level terminals as well - but Science actually unlocks stuff to craft on Settlements, upgrades for Power Armor and a lot of stuff, and INT is tied to levelling, so its much harder to dump INT.
END is another stat i like to dump. Although more HP is always nice, there's absolutely nothing on the Endurance tree that's critical to gameplay. Even on Survival, i never felt the need to have more than 1 END, i always find that if i adequately upgrade my gear, i can tank enough hits to get away with it, as long as i'm kind of careful - which suits my normal playstyle of being a stealth sniper.