Thing is, I'd need to do a lot of reading up on the Gramarie material to be familiar with it, so a campaign could be tailored to the characters. Also, the player list would have to be manageable. How many people were interested?
Also, I'd need to be able to either run combat without maps, or with fairly simple maps without having to update after every turn or two (like I have been for my 4E game, though that's a fairly unique requirement due to the necessary micromanaging of PC/NPC placement and movement issues).
If it can be run with minimal map work, then I should be able to make it work. The reason I had to call my Legend game off was due to not being able to commit the time to fully familiarizing myself with the game system, and figuring out logistics of running that game. I can't say for certain it would work out exactly the same here or not, but given a basic foundation of 3.5 I believe I understand enough the fundamentals to run the backend. Still, anything that could take any amount of pressure off my role would be useful. --edit-- I should note, I've also greatly reduced the number of PbP's I'm in and that need constant attention, and that has done wonders lately.
I suppose the most important questions to determine whether I can do this are: How many people, exactly, are interested in playing this, and what do you each want from the game?