I think the first idea I had was skipping Ascetic Style, going unarmed gish, and combining spellstrike effects with School Strike.
Here's an Oracle build. Ascetic mystery cyclopean seer of at least 12th level. Take Revelation Strike and Combat Stamina, as well as the Doomsaying and Oracular Spellstrike mysteries. Cast Quickened True Strike (From cyclopean seer bonus spells), then cast Harm and spellstrike it. Use Combat Stamina to activate Revalation Strike as a free action, applying Doomsaying to saves. Resolve this as revalation, then spell, then attack damage. You are almost guaranteed to hit and have them fail the save and the unarmed damage will deal with the 1HP clause of Harm.