(x-posted, replying to o.p.)
Rather steep S-curve. Won't impact early game much.
Then lets say mid levels, you get 1 of these per combat.
So you're gonna die no matter what, within 2 levels.
Later it'd happen every hit. While monsters are "stupid"
they aren't so stupid they wouldn't try this at all.
However ... as far as balancing things with Full Casters
every attack is a SoD, while the casters gimp themselves
slightly to compensate for their fragility.
idk might be worth a look.
I can't fairly state since I'm a fan of banning/ignoring Death by Massive Damage. Considering WotC thought 50 damage in 1 hit to be 'massive,' and considering how much damage one can do when properly optimized (infinite or Hood-levels), I say do what you will do, considering my advice.
"Normal" massive damage goes :
1/10th Hood
8/10ths the Million attacks t.o. thread
1/10th skewing the save.