Avasculate is a 7th level spell (3.5, Spell Compendium, p. 19) that simply says ' the subject is reduced to half of its current hit points (rounded down) and stunned for 1 round. On a successful Fortitude saving throw, the subject is not stunned'. It allows a fort save, but that is only for the stun effect. Only Spell Resistance can prevent the halving of current HP and luckily, Spell Resistance can be lowered/overcome by various means.
Do this a couple times and boom, the 'big numbers' Kaiju is....
2,500hp Monster. (Big Numbers Kaiju)
*Avasculate*
1,250hp Monster. (Somewhat Big Numbers Kaiju)
*Avasculate*
625hp Monster. (Kaiju)
*Avasculate*
312hp Monster (Mini-Kaiju)
*Avasculate*
156hp Monster (Just some dude)
Etc., etc.