Oh, i would absolutely love weird characters. I always played those. I think VtM, especially, rather than Werewolf or Mages/Technocrats, and of course, Hunters (which are basically what you'll see in my campaigns, simply because it's the material i've already know and played/dm'd, and because i feel like overcrowding the world with growing numbers of supertitious entities breaks immersion, because, really, how the f*** can you justify humans not knowing about everything when in a crowd there's basically always something that isn't what you think it is?).
In my Campaigns i tend to vastly diminish the degree in which the world is basically controlled by powers beyond human comprehension, and highlight the fact that living in a human-filled world is HARD for a supernatural being. There's not only the dire consequences of breaking the Masquerade, you actually have to hide, have a life beyond being kin, a beliavable one. I make the world so that even Sabbat try to at least fake their wanton slaughter as being the work of serial killers, and that even Anarchs who won't bend to either aren't completely free from bonds, as there are consequences for being stupid. I also dislike the strong judeo-christian origin on Vampires so i hold onto the Book of Nod not as scripture but as legend, and the Hunters are not necessarily of judeo-christian tradition - in fact - they can be of any faith and come in any form. Just generally, i try to tone down the amount of supernatural and of infiltration of vampires in the higher hierarchies of government. Sure, there are many, but there are also many hunters that are also very high up the hierarchy and always on the lookout for possible vampires in the chain of command. Subtlety is the name of the game in my WoD games. Don't be subtle, don't blame me when a blood hunt is declared, or the entire police force are posting your face as most-wanted, werewolves are alerted as to who you are and that you are alone, and your only option is to go to a Tzimisce and do whatever he wants you to in exchange to changing your characters appearance.