Okay, so let's assume we have a level 20 [Wu Jen 5 / Spellguard of Silverymoon 4 / Cleric 1 / Dweomerkeeper 10]. They pick up UMD as a class skill, Obtain Familiar with a feat, and proceed to do this:
Round 1: UMD a scroll of "Surge of Fortune" (Cleric 4). Might not even need to UMD; you have a CL higher than the scroll, but it's not in Cleric.
Round 2: Cast "Transcend Mortality", choosing to cast it as a touch spell (per Spellguard) and as a supernatural spell (Dweomerkeeper), but hold the charge.
Round 3: Ready an action to strike your target with the touch spell as soon as you are within reach.
Round 3: Your familiar uses your UMD ranks to activate a scroll of "Wish", using the Transport Travelers function to put you and your familiar next to your target.
Round 3: Readied action goes off, and you make a touch attack.
Round 3: Burn your immediate action in order to make the attack roll a natural 20, per "Surge of Fortune", making you automatically hit.
Round 3: Use your move action to get away (Shadow Stride, maybe?)
For the next (Wu Jen CL) rounds, you stay out of reach.
Round 3+X: Once they die from "Transcend Morality", you hit them with "Barghest's Feast". Possibly again, if you have a belt of battle. And your familiar can UMD a scroll of it.
Is there a way to survive this? Transcend Morality is not a death effect, nor negative energy, so I don't believe it would be stopped by any immunities.