ToB seems to almost defeat the purpose of a mundanes game. "You can't be wizards, but you can haul out quasi-magical attacks and teleportation effects based on a mystical understanding of your triceps."
And I'm thinking "Team Monster beats mundane PC's" approaches the old logical fallacy realm, since it completely negates the input of, you know, the DM. I'm going to assume ImperatorK is not going to declare "no casters" then haul out a level-appropriate module.
So, things to consider assuming a non-ToB "mundanes" group...
Obviously, Challenge Rating is out the window as a guide. It's a rather weak guide in normal situations, since properly played Shadows can decimate a group if they are not equipped to handle the situation.
Does the "no spellcasters" policy effect Ye Olde Magicke Shoppe? You said there would be spellcaster NPCs, but are you running mundane party in magical world or mundane party in mostly mundane world? If the latter, make your treasure hoards heavier on magic items left behind by Old Magic Empire Destroyed By Hubris and lighter on coins (which will be spent on nothing other than, potentially, the crazy stupid prices of items in the Stronghold Builder's Guidebook and the trap section of the DMG).
Factor terrain heavily into your combats. Since buff magic and battlefield control spells won't be around to the normal extent, the players should have to think tactically about cover, choke points, high ground, and other options that will keep the battle more interesting than "people with hurty things line up and stab each other." If the party is attacked by flying enemies, include a thicket of densely packed trees, a small cave, and/or other places to allow concealment and draw the enemy in close. Flyers attacking a mundane party in the open field will create a moment of "Ah crap, bad timing" dramatic tension, but the fight will just consist of "everyone draw a bow and roll attacks until the fight is over."
Have one or more people in the party with some kind of aggro-gathering mechanic.
Everyone needs a ranged weapon.
Can't think of anything else at the moment.