^ really? I didn't know that. I use the xbox 360 controller, and I only have 1 quick menu, which makes it impossible to use hotkeys at all (the 2 the controller gives you) b/c of the way the spells always default to your lefthand (as X-Codes notes). Honestly, while my gf and I are playing the hell out of Skyrim, I find the game pretty shoddily put together. In a lot of ways I play Skyrim despite it's gameplay, interface, and so on, which is pretty ridiculous.
For a small, new production house -- like Witcher 2's Red Projekt -- some of this is forgivable. For the 5th game in a series from a major house, it's not.
But, take away the mod scene, and I'd never have bothered to play the game at all ...
P.S.: did you find a good mod for hotkeys? I haven't yet.