Here's some ideas:
Orc Dungeoncrasher Fighter 6
Stats: Str > Con > everything else
Main Feats: Improved Bull Rush, Power Attack, Improved Unarmed Strike, Snap Kick
Strategy: push target into the wall and bash his head in.... LITERALLY.
(Air) Goblin Monk 3/Rogue 3
Stats: Dex/Wis > Con > Everything else
Main Feats: Weapon Finesse, Stunning Fist
Strategy: Use Stunning Fist, the sneak attack the crap out of the stunned target. May add a few ambush feats for various debuffs.
Hobgoblin Fighter 4/ Barbarian 2
Stats: Str > Dex/Con > everything else
Main feats: EWP: Dire flail, Two Weapon Fighting, Improved Sunder, Power Attack, Weapon Focus (dire flail), Dire Flail Smash (Champions of Ruin)
Strategy: This guy only works if he can get a Dire flail. Bash the target once with each end and force a Save or be dazed for 1 round.