Huh, lets take on White Wolf.
Wraith: the Oblivion - Somehow made it up to a second edition before anyone bothered to actually play a game of it. Once they did, they discovered that the system was horrid. Having a destined nemesis? Kind of cool. Making your alter ego that destined nemesis so that they advanced at EXACTLY the same rate as you (allowing you to defeat them by metaphorically sitting at home and eating potato chips)? Less cool. Making them manifest by dumping taking you over so that not only could you never meet them, but it needed either DMs or other PCs to hijack your character? This enters wallbanger territory.
Probably the system White Wolf would most like to forget producing. It was clearly driven by writers and artists, not by actual gamers who created systems that were fun to play. To this day, I'm sure there's White Wolf employees who don't understand why it failed... and others who don't understand what the first group are thinking.
Kindred of the East - So all the vampires in Asia are from a completely different line of ur-vampires who have nothing to do with other WoD vampires, are more powerful, and just happen to share certain mechanical similarities?
I knew virtually no one who really liked this system. African vampires, when they were introduced, thankfully all came from the same clans as everyone else, they just had a very different set of cultures and traditions, which made a ton of sense.
Return of the Scarlet Empress - so this entire time the main drama of the Exalted storyline has actually been a sidenote to the ACTUAL enemy, who sweeps in at the 11th hour, kicks everyone's ass, and takes over the world with nothing anyone can do about it? Being a system where all the PCs can do is either die honorably or run like scared children brings it into the straight "screw you" territory.
I'm fairly certain every single person who likes Exalted considers this book non-canon. It's a middle finger to their entire fanbase, and some people will never forgive them for it.
Chicago by Night, 1st edition - the only, the ONLY V:tM setting to EVER get two editions was Chicago by Night.
White Wolf prefers it to be remembered as only being printed once. The first edition didn't stop at getting mere game mechanics wrong (in an official White Wolf Publication), it was filled with grammatical errors and obvious mistakes, as well as featuring subject matter that was horribly written. It's nigh on legendary.