Disintegrate still makes a rather large problem, thanks to the drastically reduced HP and Fort save (looking at loosing roughly 200hp)
I assume your not optimizing to kill other PCs right?
If not, the Save DCs are not as high as you might think. It's DC 16+Mod, assuming 17+Mod for Divine's via Domain Access a quick sample looks like:
Solar, CR 23, DC 24.
Elder Brain, CR 25, DC 24.
Great Wyrm Red Dragon, CR 26, DC 24.
Corpse Tearer Linnorm, CR 28, DC 22.
Now compare to my listed Save enhancers, excluding the Moral bonus, you have a +19 bonus from items alone against these technically Epic creatures. You can beat every single one of them with a roll of 5 or higher. Assuming you even end up with so much as a +3 for Base Fortitude, you only fail when to roll a 1. And no amount of Bonus can change that since Natural 1s auto-fail.
It's a different story if the monsters are optimized so take the above at token value. I'm not going to quite say you'll never fail your Save...